Availability: In StockBiological Description:Tofacitinib(CP-690550) is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.IC50 value: 1 nM [1]Target: JAK3in vitro: CP-690550 is a specific, orally inhibitor of JAK3, it is 20- to 100-fold less potent for JAK2 and JAK1 with IC50 of 20 nM and 112 nM, respectively. CP-690550 doesn"t have potent activity against 30 other kinases (all median IC50 > 3000 nM). CP-690,550 inhibits IL-2–induced proliferation with 30-fold greater potency than its effects on GM-CSF–induced proliferation [1]. CP-690550 effectively inhibits a murine mixed lymphocyte reaction (MLR) (IC50 = 91 nM) [2]. CP-690550 potently inhibits IL-4 induced upregulation of CD23 (IC50=57 nM) and class II major histocompatibility complex (MHCII) expression (IC50=71 nM) on murine B cells [3]. in vivo: In a murine model of heterotopic heart transplantation (DBA2 donor heart into C57/BL6 host), CP-690550 results in a dose-dependent increase in survival of transplanted hearts.The EC50 (drug concentrati...Purity: >98%Molecular formula: C₁₆H₂₀N₆OMolecular Weight: 312.37Storage Instructions: Two years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSOReferences: for more information, please visit images/AffixScientific/

Affix Scientific国烟草货号： 1185887-21-1生物学描述：AB-FUBINACA是一种基于吲唑的合成大麻素（CB），其对中央CB1受体的亲和力（Ki = 0.9 nM）比JWH 018高10倍。AB-FUBINACA最初是由辉瑞公司（Pfizer，Inc.）合成的。一种有效的CB1受体调节剂，可用于潜在的治疗用途，但最近在非法草药产品中与AB-PINACA一起被发现。1,2AB-CHMINACA与AB-FUBINACA在结构上相关，但环己基取代了4-氟苯基。该化合物的生理和毒理特性尚未确定。该产品用于研究和法医应用。纯度： ≥98％分子式： C 2 0 H 2 8 N 4O 2分子量： 129.15贮存说明： -20°C粉末，2周DMSO中4°C，6个月-DMSO中80°C，2年