Availability: In StockBiological Description:Dizocilpine maleate(MK 801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nMIC50 Value: 30.5 nM[1].NMDA (N-methyl-D-aspartate) receptor antagonist (MK-801) were used to treat hyperalgesia in the diabetic neuropathic pain (DNP)[2].in vitro: Neurophysiological studies in vitro, using a rat cortical-slice preparation, demonstrates a potent, selective, and noncompetitive antagonistic action of dizocilpine on depolarizing responses to N-Me-D-Asp but not to kainate or quisqualate. The potencies of phencyclidine, ketamine, SKF 10047, and the enantiomers of dizocilpine as N-Me-D-Asp antagonists correlate closely (r = 0.99) with their potencies as inhibitors of [3H] dizocilpine binding. This suggests that the dizocilpine binding sites are associated with N-Me-D-Asp receptors and provides an explanation for the mechanism of action of dizocilpine as an anticonvulsant[1]. The cytotoxicity of MK-801 on cultured microglia was also investigated. Cytotoxicity of MK-801 was reduced by t...Purity: >98%Molecular formula: C₂₀H₁₉NO₄Molecular Weight: 337.37Storage Instructions: Two years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSOReferences: for more information, please visit images/AffixScientific/

Affix Scientific国烟草货号： 1185887-21-1生物学描述：AB-FUBINACA是一种基于吲唑的合成大麻素（CB），其对中央CB1受体的亲和力（Ki = 0.9 nM）比JWH 018高10倍。AB-FUBINACA最初是由辉瑞公司（Pfizer，Inc.）合成的。一种有效的CB1受体调节剂，可用于潜在的治疗用途，但最近在非法草药产品中与AB-PINACA一起被发现。1,2AB-CHMINACA与AB-FUBINACA在结构上相关，但环己基取代了4-氟苯基。该化合物的生理和毒理特性尚未确定。该产品用于研究和法医应用。纯度： ≥98％分子式： C 2 0 H 2 8 N 4O 2分子量： 129.15贮存说明： -20°C粉末，2周DMSO中4°C，6个月-DMSO中80°C，2年