Availability: In StockBiological Description:(+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2).IC50 Value: 77 nM(for BRD4(1)); 33 nM( for BRD4(2))Target: BRD4in vitro: (+)-JQ1 enantiomer binds directly into the Kac binding site of BET bromodomains. (+)-JQ1 (500 nM) binds BRD4 competitively with chromatin resulting in differentiation and growth arrest of NMC cells. (+)-JQ1 (500 nM) attenuates rapid proliferation of NMC 797 and Per403 cell lines as demonstrated by reduced Ki67 staining. (+)-JQ1 (500 nM) potently decreases expression of both BRD4 target genes in NMC 797 cells. (+)-JQ1 inhibits cellular viability with IC50 of 4 nM in NMC 11060 cells. (+)-JQ1 results in robust inhibition of MYC expression in MM cell lines. (+)-JQ1 inhibits proliferating of KMS-34 and LR5 with IC50 of 68 nM and 98 nM, respectively. (+)-JQ1 (500 nM)-treated MM.1S cells results in a pronounced decrease in the proportion of cells in S-phase, with a concomitant increase in cells arrested in G0/G1. (+)-JQ1 (500 nM) results in pronounced cellu...Purity: >98%Molecular formula: C₂₃H₂₅ClN₄O₂SMolecular Weight: 456.99Storage Instructions: Two years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSOReferences: for more information, please visit images/AffixScientific/

Affix Scientific国烟草货号： 1185887-21-1生物学描述：AB-FUBINACA是一种基于吲唑的合成大麻素（CB），其对中央CB1受体的亲和力（Ki = 0.9 nM）比JWH 018高10倍。AB-FUBINACA最初是由辉瑞公司（Pfizer，Inc.）合成的。一种有效的CB1受体调节剂，可用于潜在的治疗用途，但最近在非法草药产品中与AB-PINACA一起被发现。1,2AB-CHMINACA与AB-FUBINACA在结构上相关，但环己基取代了4-氟苯基。该化合物的生理和毒理特性尚未确定。该产品用于研究和法医应用。纯度： ≥98％分子式： C 2 0 H 2 8 N 4O 2分子量： 129.15贮存说明： -20°C粉末，2周DMSO中4°C，6个月-DMSO中80°C，2年